Comments on: Help Vinay & Sameer – SF http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/ All that flavorful brownness in one savory packet Sat, 30 Nov 2013 11:11:28 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: sachin http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-149484 sachin Thu, 12 Jul 2007 23:40:16 +0000 http://sepiamutiny.com?p=4535#comment-149484 <p>I just gave my swab....but I am surprised how there is no bone marrow database in India...With a population like we have back home, it would be so much more easier to find a match.... who can we work with to make this happen?</p> I just gave my swab….but I am surprised how there is no bone marrow database in India…With a population like we have back home, it would be so much more easier to find a match…. who can we work with to make this happen?

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By: SM Intern http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-147288 SM Intern Tue, 03 Jul 2007 17:23:01 +0000 http://sepiamutiny.com?p=4535#comment-147288 <p>notammpnstrr/notamonster:</p> <p>How about you live up to your handle by not leaving such inappropriate comments? You are disgusting.</p> notammpnstrr/notamonster:

How about you live up to your handle by not leaving such inappropriate comments? You are disgusting.

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By: shripa http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-147183 shripa Mon, 02 Jul 2007 20:39:26 +0000 http://sepiamutiny.com?p=4535#comment-147183 <p>i know both sameer and his wife reena.</p> <p>sameer is a wonderful human... always helpful and kind and considerate. it's rare to see some our age instinctively put other people before himself. please, it's time to help him as much as he's helped others!</p> <p>and reena is the funniest and sweetest person i know. i've never spent a day with her and not laughed until i cried. i don't want to image her ever not smiling or laughing!</p> <p>please spread the word and help them.</p> i know both sameer and his wife reena.

sameer is a wonderful human… always helpful and kind and considerate. it’s rare to see some our age instinctively put other people before himself. please, it’s time to help him as much as he’s helped others!

and reena is the funniest and sweetest person i know. i’ve never spent a day with her and not laughed until i cried. i don’t want to image her ever not smiling or laughing!

please spread the word and help them.

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By: TheenPathi http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-146818 TheenPathi Fri, 29 Jun 2007 02:32:36 +0000 http://sepiamutiny.com?p=4535#comment-146818 <blockquote>how long after registering does it take for my information to be entered into the donor database?</blockquote> <p>I asked this question at the donor drive I went to (which was for Vinay). One of the volunteers, who works for a blood bank, said that normally, it takes 4-6 weeks for a donor's information to be entered into the database. However, when the samples are collected at a drive organized on behalf of a patient with little time to find a match, they expedite the processing of the sample so that it can be entered in as little as a few days. Don't know if she was just saying this to make me feel better for registering on behalf of Vinay (whose website now says 11 days left), but I'll take it on faith.</p> how long after registering does it take for my information to be entered into the donor database?

I asked this question at the donor drive I went to (which was for Vinay). One of the volunteers, who works for a blood bank, said that normally, it takes 4-6 weeks for a donor’s information to be entered into the database. However, when the samples are collected at a drive organized on behalf of a patient with little time to find a match, they expedite the processing of the sample so that it can be entered in as little as a few days. Don’t know if she was just saying this to make me feel better for registering on behalf of Vinay (whose website now says 11 days left), but I’ll take it on faith.

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By: Shalu http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-146802 Shalu Fri, 29 Jun 2007 01:23:00 +0000 http://sepiamutiny.com?p=4535#comment-146802 <p>Sameer is a friend of mine and I urge all of you to go out there and please get registered if you haven't.</p> <p>My cousin recently ordered her kit through the mail and said it was incredibly easy and cheap (free)...not to mention convenient.</p> Sameer is a friend of mine and I urge all of you to go out there and please get registered if you haven’t.

My cousin recently ordered her kit through the mail and said it was incredibly easy and cheap (free)…not to mention convenient.

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By: Rahul http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-146786 Rahul Fri, 29 Jun 2007 00:11:05 +0000 http://sepiamutiny.com?p=4535#comment-146786 <p>The baby might survive avian flu 5.0, but he might also equate himself to paneer dosa. Or worse, eat it. And that's no good.</p> The baby might survive avian flu 5.0, but he might also equate himself to paneer dosa. Or worse, eat it. And that’s no good.

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By: Sahej http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-146784 Sahej Fri, 29 Jun 2007 00:07:53 +0000 http://sepiamutiny.com?p=4535#comment-146784 <p>make sure he's a fan of indian tea, everything else is gravy</p> make sure he’s a fan of indian tea, everything else is gravy

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By: portmanteau http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-146782 portmanteau Fri, 29 Jun 2007 00:00:15 +0000 http://sepiamutiny.com?p=4535#comment-146782 <blockquote> survival in case of a super-plague</blockquote> <p>razib, i thank you for the reassurance. i don't know who i'll end up with, but that's one more way to placate the 'rents, just in case i don't bring IIT boy (who, naturally, belongs to my linguistic community) home. "ma, at least our baby will survive avian flu 5.0."</p> survival in case of a super-plague

razib, i thank you for the reassurance. i don’t know who i’ll end up with, but that’s one more way to placate the ‘rents, just in case i don’t bring IIT boy (who, naturally, belongs to my linguistic community) home. “ma, at least our baby will survive avian flu 5.0.”

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By: razib http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-146762 razib Thu, 28 Jun 2007 22:55:34 +0000 http://sepiamutiny.com?p=4535#comment-146762 <p>p.s. as someone who will have biracial children i would like to emphasize the upside of being genetically rare: <b>likely immunity to common pathogenics, and/or survival in case of a super-plague</b>. the way evolution works microbes develop strategies to overcome <b>common immune profiles</b>. if yours is rare, then you will almost certainly not be as susceptible.</p> p.s. as someone who will have biracial children i would like to emphasize the upside of being genetically rare: likely immunity to common pathogenics, and/or survival in case of a super-plague. the way evolution works microbes develop strategies to overcome common immune profiles. if yours is rare, then you will almost certainly not be as susceptible.

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By: razib http://sepiamutiny.com/blog/2007/06/28/help_vinay_same_2/comment-page-1/#comment-146758 razib Thu, 28 Jun 2007 22:53:12 +0000 http://sepiamutiny.com?p=4535#comment-146758 <p><i>Say a South Indian marries a Caucasian & their kid marries a Chinese & then they have a kid, that final kid is some exotic mix of SouthIndian+Caucasian+Chinese. It will be next to impossible to find a match for that kid if he gets AML because his ethnic group probably has maybe half a dozen people on entire pla</i></p> <p>you're exaggerating a bit, but yes, this is an issue. people of thai-european ancestry in the USA who need matches will go to thailand specifically because that combination is more common there (lots of white male expats + thai women). in any case, by the time people who are so genetically mixed appear on the scene in large numbers</p> <p>1) there will be more of them</p> <p>2) we will (hopefully) be able to grow organs (fingers crossed)</p> <p>also, the number of HLA loci are finite, you get your alleles from half of your parents. the immune profile isn't a mixture, it is a discrete slice of both parents. this means that the increase is diversity isn't as great as you assume assuming a blending analogy. specifically, the number of genetic loci is small enough that sampling variance is going to make someone deviated from the perfect storm of being 1/4 chettier, 1/4 chinese, 1/4 white and 1/4 african.</p> <p>in any case, let's remember the effect of numbers. even if the chance of not matching is 99.995% as you increase the sample space into thousands the expectation of a match within that space increases toward 100%.</p> Say a South Indian marries a Caucasian & their kid marries a Chinese & then they have a kid, that final kid is some exotic mix of SouthIndian+Caucasian+Chinese. It will be next to impossible to find a match for that kid if he gets AML because his ethnic group probably has maybe half a dozen people on entire pla

you’re exaggerating a bit, but yes, this is an issue. people of thai-european ancestry in the USA who need matches will go to thailand specifically because that combination is more common there (lots of white male expats + thai women). in any case, by the time people who are so genetically mixed appear on the scene in large numbers

1) there will be more of them

2) we will (hopefully) be able to grow organs (fingers crossed)

also, the number of HLA loci are finite, you get your alleles from half of your parents. the immune profile isn’t a mixture, it is a discrete slice of both parents. this means that the increase is diversity isn’t as great as you assume assuming a blending analogy. specifically, the number of genetic loci is small enough that sampling variance is going to make someone deviated from the perfect storm of being 1/4 chettier, 1/4 chinese, 1/4 white and 1/4 african.

in any case, let’s remember the effect of numbers. even if the chance of not matching is 99.995% as you increase the sample space into thousands the expectation of a match within that space increases toward 100%.

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